Sjögren’s syndrome is a chronic autoimmune disorder characterized by inflammation of the glands that produce moisture, such as the salivary glands and tear glands (lacrimal glands). This inflammation leads to decreased production of saliva and tears, resulting in symptoms of dry mouth (xerostomia) and dry eyes (keratoconjunctivitis sicca), among other systemic manifestations.

Here are some key points about Sjögren’s syndrome:

1. Autoimmune Nature: Sjögren’s syndrome is classified as an autoimmune disorder because the body’s immune system mistakenly attacks its own moisture-producing glands. The exact cause of this autoimmune response is not fully understood, but a combination of genetic predisposition and environmental factors is thought to play a role.
2. Primary vs. Secondary: Sjögren’s syndrome can occur either as a primary condition, in which it occurs alone, or as a secondary condition associated with another autoimmune disorder, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), or scleroderma. When Sjögren’s syndrome occurs in conjunction with another autoimmune disorder, it is referred to as secondary Sjögren’s syndrome.
3. Symptoms: The hallmark symptoms of Sjögren’s syndrome are dry mouth and dry eyes, which can cause discomfort, difficulty speaking or swallowing, and visual disturbances. Other common symptoms may include fatigue, joint pain or swelling, dry skin, vaginal dryness, and recurrent oral or vaginal yeast infections. In some cases, Sjögren’s syndrome can also affect other organs and tissues, leading to systemic complications.
4. Diagnosis: Diagnosis of Sjögren’s syndrome involves a combination of medical history, physical examination, and specialized tests. These may include blood tests to detect specific autoantibodies associated with Sjögren’s syndrome (such as anti-SSA/Ro and anti-SSB/La antibodies), imaging studies to evaluate glandular function, and/or salivary gland biopsy to assess for characteristic inflammatory changes.
5. Treatment: Treatment of Sjögren’s syndrome focuses on relieving symptoms, preventing complications, and managing systemic manifestations. This may involve a combination of approaches, including the use of artificial tears and saliva substitutes to alleviate dryness, medications to reduce inflammation and suppress the immune system, and lifestyle modifications to promote oral and ocular health. In cases of secondary Sjögren’s syndrome, treatment may also target the underlying autoimmune disorder.
6. Prognosis: Sjögren’s syndrome is a chronic condition that tends to persist throughout life. While it is not curable, symptoms can often be managed effectively with appropriate treatment and self-care measures. However, Sjögren’s syndrome can vary widely in severity and may lead to complications affecting various organs and systems, underscoring the importance of regular monitoring and comprehensive management.

In summary, Sjögren’s syndrome is an autoimmune disorder characterized by inflammation of the moisture-producing glands, resulting in symptoms of dry mouth, dry eyes, and potentially systemic complications. Early diagnosis and appropriate management are essential for optimizing quality of life and minimizing the impact of the condition on overall health.